Ophth - T-Blue

(Trypan Blue 0.06%)
Staining Solution for Ophthalmic Surgery


Drug Description

T-Blue (trypan blue ophthalmic solution) 0.06% is a sterile solution of trypan blue (an acid di-azo group dye). T-Blue is a selective tissue staining agent for use as a medical aid in ophthalmic surgery.

Each mL of T-Blue 0.06% contains: 0.6 mg trypan blue; 1.9 mg sodium mono-hydrogen orthophosphate (Na2HPO4.2H2O); 0.3 mg sodium di-hydrogen orthophosphate (NaH2PO4•2H2O); 8.2 mg sodium chloride (NaCl); and water for injection. The pH is 7.3 - 7.6. The osmolality is 257-314 mOsm/kg.

The drug substance trypan blue has the chemical name 3,3'-[(3,3'-dimethyl-4,4'-biphenylylene) bis (azo)] bis(5-amino-4-hydroxy-2,7-naphthalenedisulfonic acid) tetra sodium salt, a molecular weight of 960.8, a molecular formula of C34H24N6Na4O14S4,

Indications

T-Blue is indicated for use as an aid in ophthalmic surgery by staining the anterior capsule of the lens.

Dosage and Administration
Cataract surgery

T-Blue is packaged in a 2.25 mL syringe to which a blunt cannula has to be attached.

After opening the eye, an air bubble is injected into the anterior chamber of the eye in order to minimize dilution of T-Blue by the aqueous. T-Blue is carefully applied onto the anterior lens capsule using a blunt cannula. Sufficient staining is achieved as soon as the dye has contacted the capsule. The anterior chamber is then irrigated with balanced salt solution to remove all excess dye. An anterior capsulotomy can then be performed.

Storage

T-Blue is stored at 15-25°C (59-77°F). Protect from direct sunlight.

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